Publications

Members of the Michnick Lab
*Corresponding Author
#Equal Contribution

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PubMed

2023

  1. R Ravindran, IOL Bacellar, X Castellanos-Girouard, Z Zhang, L Kisley, SW Michnick*.
    Peroxisome biogenesis initiated by protein phase separation. (Nature, 2023).

  2. L González, D Kolbin, C Trahan, C Jeronimo, F Robert, M Oeffinger, K Bloom, SW Michnick*.
    Adaptive partitioning of a gene locus to the nuclear envelope in Saccharomyces cerevisiae is driven by polymer-polymer phase separation. (Nat. Commun., 2023).

2022

  1. DS Marks*, SW Michnick*.
    Democratizing the mapping of gene mutations to protein biophysics. (Nature, 2022).

  2. SW Michnick*, ED Levy*.
    The modular cell gets connected. (Science, 2022).

2021

  1. LP Bergeron-Sandoval, S Kumar, HK Heris, CLA Chang, CE Cornell, SL Keller, P François, AG Hendricks, AJ Ehrlicher, RV Pappu*, SW Michnick*.
    Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling. (PNAS, 2021).

  2. FA Fellouse*, S Miersch, C Chen, SW Michnick*.
    Structure-based Design of a Specific, Homogenous Luminscence Enzyme Reporter Assay for SARS-CoV-2. (J. Mol. Biol., 2021).

2020

  1. L Gauthier, B Stynen, AWR Serohijos*, SW Michnick*.
    Genetics’ Piece of the PI: Inferring the Origin of Complex Traits and Disease from Proteome-Wide Protein-Protein Interactions Dynamics. (BioEssays, 2020).

2019

  1. R Hurtubise, C Audiger, MC Dominguez-Punaro, G Chabot-Roy, G Chognard, L Raymond-Marchand, L Coderre, S Chemtob, SW Michnick, JD Rioux, S Lesage*.
    Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways. (Cytokine, 2019).

  2. M Shayegan, R Tahvildari, K Metera, L Kisley, SW Michnick*, Sabrina R Leslie*.
    Probing inhomogeneous diffusion in the microenvironments of phase-separated polymers under confinement. (J. Am. Chem. Soc., 2019).

  3. SW Michnick*, LP Bergeron-Sandoval, R Pappu, P François, AG Hendricks, AJ Ehrlicher, HK Heris.
    A protein condensate drives actin-independent endocytosis. (Biophys. J., 2019).

  4. A Kelil, SW Michnick*.
    Predicted amino acid motif repeats in proteins potentially encode extensive multivalent macromolecular assemblies in the human proteome. (Curr. Opin. Struct. Biol., 2019).

2018

  1. S Boisson-Dupuis*#, N Ramirez-Alejo#, Z Li, E Patin, G Rao, G Kerner, CK Lim, DN Krementsov, N Hernandez, CS Ma, Q Zhang, J Markle, R Martinez-Barricarte, K Payne, R Fisch, C Deswarte, J Halpern, M Bouaziz, J Mulwa, D Sivanesan, T Lazarov, R Naves, P Garcia, Y Itan, B Boisson, A Checchi, F Jabot-Hanin, A Cobat, A Guennoun, CC Jackson, S Pekcan, Z Caliskaner, J Inostroza, BT Costa-Carvalho, JAT de Albuquerque, H Garcia-Ortiz, L Orozco, T Ozcelik, A Abid, IA Rhorfi, H Souhi, HN Amrani, A Zegmout, F Geissmann, SW Michnick, I Muller-Fleckenstein, B Fleckenstein, A Puel, MJ Ciancanelli, N Marr, H Abolhassani, ME Balcells, A Condino-Neto, A Strickler, K Abarca, C Teuscher, HD Ochs, I Reisli, EH Sayar, J El-Baghdadi, J Bustamante, L Hammarström, SG Tangye, S Pellegrini, L Quintana-Murci, L Abel, JL Casanova*.
    Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant. (Sci. Immunol., 2018).

  2. B Stynen#, D Abd-Rabbo#, J Kowarzyk, L Miller-Fleming, SK Aulakh, P Garneau, M Ralser, SW Michnick*.
    Changes of cell biochemical states are revealed in protein homomeric complex dynamics. (Cell, 2018).

  3. LP Bergeron-Sandoval, SW Michnick*.
    Mechanics, structure and function of biopolymer condensates. (J. Mol. Biol., 2018).

  4. SW Michnick*, LP Bergeron-Sandoval.
    Why does biopolymer condensation matter? (Nat. Rev. Mol. Cell Biol., 2018).

  5. U Weill, I Yofe, E Sass, B Stynen, D Davidi, J Natarajan, R Ben-Menachem, Z Avihou, O Goldman, N Harpaz, S Chuartzman, K Kniazev, B Knoblach, J Laborenz, F Boos, J Kowarzyk, S Ben-Dor, E Zalckvar, JM Herrmann, RA Rachubinski, O Pines, D Rapaport, SW Michnick, ED Levy, M Schuldiner*.
    Genome-wide SWAp-Tag yeast libraries for proteome exploration. (Nat. Methods., 2018).

  6. LP Bergeron-Sandoval, HK Heris, A Hendricks, A Ehrlicher, P François, R Pappu, SW Michnick*.
    Mechanical Energy of Protein Phase Separation Shapes Cell Membranes. (Available at SSRN, 2018).

  7. B Stynen, D Abd-Rabbo, J Kowarzyk, L Miller-Fleming, M Ralser, SW Michnick*.
    A novel yeast global genetic screen reveals that metformin induces an iron deficiency-like state. (Available at SSRN, 2018).

2017

  1. D Abd-Rabbo, SW Michnick*.
    Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast D Abd-Rabbo, SW Michnick. (BMC syst. biol., 2017).

  2. SW Michnick*.
    More than One Way to Skin a Catalyst. (Cell Chem. Biol., 2017).

  3. A Kelil, B Dubreuil, ED Levy, SW Michnick*.
    Exhaustive search of linear information encoding protein-peptide recognition. (PLoS Comput. Biol., 2017).

2016

  1. SW Michnick*, ED Levy, CR Landry, J Kowarzyk, V Messier.
    The dihydrofolate reductase Protein-Fragment complementation assay: A Survival-Selection assay for Large-Scale analysis of Protein-Protein interactions. (Cold Spring Harb. Protoc., 2016).

  2. PH Ear, J Kowarzyk, SW Michnick*.
    Dissecting the Contingent Interactions of Protein Complexes with the Optimized Yeast Cytosine Deaminase Protein-Fragment Complementation Assay. (Cold Spring Harb. Protoc., 2016).

  3. SW Michnick*, CR Landry, ED Levy, G Diss, PH Ear, J Kowarzyk, MK Malleshaiah, V Messier, E Tchekanda.
    Protein-Fragment complementation assays for large-scale analysis, functional dissection, and spatiotemporal dynamic studies of protein-protein interactions in living cells. (Cold Spring Harb. Protoc., 2016).

  4. M Malleshaiah, E Tchekanda, SW Michnick*
    Real-Time Protein-Fragment Complementation Assays for Studying Temporal, Spatial, and Spatiotemporal Dynamics of Protein-Protein Interactions in Living Cells. (Cold Spring Harb. Protoc., 2016).

  5. C Li, JIS MacDonald, A Talebian, J Leuenberger, C Seah, SH Pasternak, SW Michnick, SO Meakin*.
    Unravelling the mechanism of TrkA-induced cell death by macropinocytosis in medulloblastoma Daoy cells. (Mol. Cell. Biol., 2016).

  6. A Kelil, ED Levy, SW Michnick*.
    Evolution of domain–peptide interactions to coadapt specificity and affinity to functional diversity. (PNAS, 2016).

  7. LP Bergeron-Sandoval, N Safaee, SW Michnick*.
    Mechanisms and consequences of macromolecular phase separation. (Cell, 2016).

  8. Guzmán Sánchez-Fernández, Sofía Cabezudo, Álvaro Caballero, Carlota García-Hoz, Gregory G Tall, Javier Klett, SW Michnick, Federico Mayor*, Catalina Ribas*.
    Protein kinase C ζ interacts with a novel binding region of Gαq to act as a functional effector. (J. Biol. Chem., 2016).

  9. D Sivanesan, C Beauchamp, C Quinou, J Lee, S Lesage, S Chemtob, JD Rioux, SW Michnick*.
    IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking. (J. Biol. Chem., 2016).

  10. PH Ear, J Kowarzyk, MJ Booth, D Abd-Rabbo, K Shulist, C Hall, J Vogel, SW Michnick*.
    Combining the Optimized Yeast Cytosine Deaminase Protein Fragment Complementation Assay and an In Vitro Cdk1 Targeting Assay to Study the Regulation of the γ-Tubulin Complex. (J. Biol. Chem., 2016).

2015

  1. R Rock, V Bachmann, HC Bhang, M Malleshaiah, P Raffeiner, JE Mayrhofer, PM Tschaikner, K Bister, P Aanstad, MG Pomper, SW Michnick, E Stefan*.
    In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs. (Sci. Rep., 2015).
  2. E Kanshin#, LP Bergeron-Sandoval#, SS Isik, P Thibault*, SW Michnick*.
    A cell-signaling network temporarily resolves specific versus promiscuous phosphorylation. (Cell. Rep., 2015).
  3. I Remy, SW Michnick*.
    Mapping biochemical networks with protein fragment complementation assays. (Protein-Protein Interactions: Methods and Applications, 2015).